Virtual Alchemies: Can New Learning Technologies Transform Police Training?

This was a collaborative action research project with three, mixed method evaluation cycles. Its aim was to increase the impact of new learning technologies (NLT) in two Police Forces. The first reconnaissance cycle found a significant absence of uptake for one computer based training system (<1% impact after five years) with only assumptions of ‘technological determinism’ driving the process. A range of individual, work related and cultural factors were illuminated, towards understanding how the Force might become a ‘network’ organisation, where technology fundamentally transforms how work is done (Symon, 2000). Following the qualitative interview study, a quantitative survey was carried out with 164 respondents on the areas of concern for NLT in the Police. Factor analysis of this data reinforced a parsimonious five factor solution, accounting for 55% of the variance and on which to proceed with cycles two and three. In the second cycle, 130 Police Probationers completed a battery of psychometrics to assess individual difference factors associated with successful outcomes in training with NLT. Results showed 27% of the variance on a bespoke NLT learning measure was predicted by computer attitudes. Age, gender, education, motivational and almost all personality measures offered no significant contribution to explaining the data. The bespoke learning criterion was used as a pre-test, post-test and retention measure and showed significant increases in knowledge were gained from NLT: effective and efficient learning was evidenced. Also in the second cycle, a sub-sample of (n=20-34) Probationers participated in two stages of repertory grid interviews rating different elements of Police training methods. From these data an ‘Ideal Probationer Learning Event’ (IPLE) model was proposed. This was stable over time and positioned NLT within a conceptual structure that identified preferred and non-preferred construct poles equating to four dimensions along which Police officers reliably rated any training event. In essence, it highlighted sites of perceived credibility and offered these as levers for creative change. Follow-up work with 120 Probationers using another example of NLT explored how integration of learning from NLT could occur from a learner-centered point of view, using an interpretive concept mapping technique. This illuminated sites of power exchange and the location of ‘ownership’ of learning in Police culture. The IPLE model was used to direct the third cycle which included constructivist and contingency perspectives. It was propsed that by creatively designing an NLT event to increase elements of the preferred constructs discovered in cycle two, integration of an NLT event would enable the transformative properties of NLT as a to manifest themselves. A sample of up to 60 Police Staff used an NLT package alongside a bespoke, collaborative e-learning group. Criterions were developed according to skill breadth, frequency and difficulty and significant increases in learning were not only found, but maintained following completion of NLT when retention was measured. The e-learning group brought some of the credible elements of training to the NLT event, thereby constituting a ‘unique solution’ (Seltzer, 1971). It created peer learning groups, despite geographical separation. Data for each level of Kirkpatrick’s (1959; 1960) ‘best practice’ training evaluation model was collected enabling the conclusion that creative integration is key to a network uptake of NLT

The Independent Study: A Review of Content and Purpose (Worcester Business School Learning & Teaching Project)

To understand current ideas as to ‘Best Practice’ in the design and process of the undergraduate Independent Study (IS) in order that they can be discussed collectively with Staff at the Away Day in November and incorporated into the IS preparation (including related modules; notably on Research Methods) and supervision processes at University of Worcester Business School

"Photobiomics" : can light, including photobiomodulation, alter the microbiome?

Objective: The objective of this review is to consider the dual effects of microbiome and photobiomodulation (PBM) on human health and to suggest a relationship between these two as a novel mechanism. Background: PBM describes the use of low levels of visible or near-infrared (NIR) light to heal and stimulate tissue, and to relieve pain and inflammation. In recent years, PBM has been applied to the head as an investigative approach to treat diverse brain diseases such as stroke, traumatic brain injury (TBI), Alzheimer's and Parkinson's diseases, and psychiatric disorders. Also, in recent years, increasing attention has been paid to the total microbial population that colonizes the human body, chiefly in the gut and the mouth, called the microbiome. It is known that the composition and health of the gut microbiome affects many diseases related to metabolism, obesity, cardiovascular disorders, autoimmunity, and even brain disorders. Materials and methods: A literature search was conducted for published reports on the effect of light on the microbiome. Results: Recent work by our research group has demonstrated that PBM (red and NIR light) delivered to the abdomen in mice, can alter the gut microbiome in a potentially beneficial way. This has also now been demonstrated in human subjects. Conclusions: In consideration of the known effects of PBM on metabolomics, and the now demonstrated effects of PBM on the microbiome, as well as other effects of light on the microbiome, including modulating circadian rhythms, the present perspective introduces a new term "photobiomics" and looks forward to the application of PBM to influence the microbiome in humans. Some mechanisms by which this phenomenon might occur are considered

A randomized placebo-controlled study of a transcranial photobiomodulation helmet in Parkinson’s disease : post-hoc analysis of motor outcomes

Emerging evidence is increasingly supporting the use of transcranial photobiomodulation (tPBM) to improve symptoms of neurodegenerative diseases, including Parkinson’s disease (PD). The objective of this study was to analyse the safety and efficacy of tPBM for PD motor symptoms. The study was a triple blind, randomized placebo-controlled trial with 40 idiopathic PD patients receiving either active tPBM (635 nm plus 810 nm LEDs) or sham tPBM for 24 min per day (56.88J), six days per week, for 12 weeks. The primary outcome measures were treatment safety and a 37-item MDS-UPDRS-III (motor domain) assessed at baseline and 12 weeks. Individual MDS-UPDRS-III items were clustered into sub-score domains (facial, upper-limb, lower-limb, gait, and tremor). The treatment produced no safety concerns or adverse events, apart from occasional temporary and minor dizziness. There was no significant difference in total MDS-UPDRS-III scores between groups, presumably due to the placebo effect. Additional analyses demonstrated that facial and lower-limb sub-scores significantly improved with active treatment, while gait and lower-limb sub-scores significantly improved with sham treatment. Approximately 70% of participants responded to active treatment (≥5 decrease in MDS-UPDRS-III score) and improved in all sub-scores, while sham responders improved in lower-limb sub-scores only. tPBM appears to be a safe treatment and improved several PD motor symptoms in patients that responded to treatment. tPBM is proving to be increasingly attractive as a possible non-pharmaceutical adjunct therapy

The effect of photobiomodulation on the brain during wakefulness and sleep

Over the last seventy years or so, many previous studies have shown that photobiomodulation, the use of red to near infrared light on body tissues, can improve central and peripheral neuronal function and survival in both health and in disease. These improvements are thought to arise principally from an impact of photobiomodulation on mitochondrial and non-mitochondrial mechanisms in a range of different cell types, including neurones. This impact has downstream effects on many stimulatory and protective genes. An often-neglected feature of nearly all of these improvements is that they have been induced during the state of wakefulness. Recent studies have shown that when applied during the state of sleep, photobiomodulation can also be of benefit, but in a different way, by improving the flow of cerebrospinal fluid and the clearance of toxic waste-products from the brain. In this review, we consider the potential differential effects of photobiomodulation dependent on the state of arousal. We speculate that the effects of photobiomodulation is on different cells and systems depending on whether it is applied during wakefulness or sleep, that it may follow a circadian rhythm. We speculate further that the arousal-dependent photobiomodulation effects are mediated principally through a biophoton – ultra-weak light emission – network of communication and repair across the brain

DNA Polymerase Epsilon Deficiency Causes IMAGe Syndrome with Variable Immunodeficiency.

During genome replication, polymerase epsilon (Pol ε) acts as the major leading-strand DNA polymerase. Here we report the identification of biallelic mutations in POLE, encoding the Pol ε catalytic subunit POLE1, in 15 individuals from 12 families. Phenotypically, these individuals had clinical features closely resembling IMAGe syndrome (intrauterine growth restriction [IUGR], metaphyseal dysplasia, adrenal hypoplasia congenita, and genitourinary anomalies in males), a disorder previously associated with gain-of-function mutations in CDKN1C. POLE1-deficient individuals also exhibited distinctive facial features and variable immune dysfunction with evidence of lymphocyte deficiency. All subjects shared the same intronic variant (c.1686+32C>G) as part of a common haplotype, in combination with different loss-of-function variants in trans. The intronic variant alters splicing, and together the biallelic mutations lead to cellular deficiency of Pol ε and delayed S-phase progression. In summary, we establish POLE as a second gene in which mutations cause IMAGe syndrome. These findings add to a growing list of disorders due to mutations in DNA replication genes that manifest growth restriction alongside adrenal dysfunction and/or immunodeficiency, consolidating these as replisome phenotypes and highlighting a need for future studies to understand the tissue-specific development roles of the encoded proteins

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant